2月24日，浙江大学团队在《神经元》（Neuron）发表论文Endogenous retrovirus-derived RNA-DNA hybrids induce microglial synaptic pruning in autism models，报告他们发现内源性逆转录病毒（ERV，一类特殊的逆转座序列，在基因组中拥有大量序列相似的拷贝）衍生的RNA-DNA杂交体诱导自闭症模型中的小胶质细胞突触修剪。研究团队使用已被美国FDA批准用于治疗HIV感染的逆转录酶抑制剂进行早期干预，能够显著抑制ERV的逆转录活性，从源头上减少RNA-DNA杂交体的形成，进而降低补体分子的C4b表达、减轻小胶质细胞的过度修剪，最终挽救小鼠的自闭症核心症状。
When disaster strikes on a flight these days, it’s almost never the way we fear. The wings won’t rip off in a gale. The plane won’t get thrown into a mountain. In the seven decades since the first paying passengers flew on a commercial jet airliner—from London to Johannesburg in 1952—the number of commercial flights has increased exponentially, while the risk of dying on one has grown incredibly small. “It works out to a probability of fatal injury of one in forty-six million flights on U.S. and E.U. airplanes,” Jacob Zeiger, the air-safety investigator at Boeing, told me. When an accident does happen, it’s usually because of human error or a ground collision or some combination of factors, including the simple act of walking around on a bumpy flight.
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